From: Subject: First advance in pancreatic cancer treatment in a decade offers new hope Date: Sun, 15 Apr 2007 16:20:31 -0400 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C77F79.FD09D980" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3028 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C77F79.FD09D980 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.news-medical.net/?id=10007 First advance in pancreatic cancer treatment in a = decade offers new hope
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First advance in pancreatic cancer treatment in a = decade=20 offers new hope

Medical = Studies/Trials
Published: Sunday, 15-May-2005 =
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The first advance in pancreatic cancer = treatment in=20 a decade has been achieved by researchers in a=20 Canadian-led study, and at last gives some = encouragement=20 to scientists and invigorates a field that has=20 experienced more than its share of disheartening = failures.

The research has found that combining a new = targeted=20 cancer drug, erlotinib, with conventional = chemotherapy=20 led to a modest increase in survival for people=20 diagnosed with pancreatic cancer, one of the = most=20 treatment-resistant forms of the disease.

Lead investigator Dr. Malcolm Moore a medical = oncologist at Princess Margaret Hospital = in Toronto,=20 says it has been 'a really tough nut to crack, = and this=20 is the first kind of crack they have seen in 10 = years in=20 terms of something that does appear to work on=20 pancreatic cancer'.

Pancreatic cancer has one of the poorest = survival=20 rates and in that respect is probably one of the = worst=20 cancers you can get. The advances against the = cancer=20 have been few and far between.

Dr. Moore was asked to present the findings = at the=20 prestigious annual meeting of the American = Society of=20 Clinical Oncologists.

The study which was funded by the National=20 Cancer Institute of Canada, the research arm = of the=20 Canadian=20 Cancer Society, followed 569 patients from = North=20 America, Australia, Asia, Europe and Israel, and = OSI=20 Pharmaceuticals, which developed the drug, = also=20 supported the trial.

In the trial, the team found that patients = who=20 received erlotinib in combination with = gemcitabine had a=20 24 per cent improvement in length of survival = compared=20 to patients who received gemcitabine alone. = Unlike=20 traditional chemotherapies, which cause = unpleasant=20 side-effects, erlotinib produced only mild = side-effects=20 and was generally well tolerated.

However on a sobering note they still found = that=20 survival times were short, and few, if any, of = the=20 people who took part in the trial are alive to = learn of=20 the findings.

To date, only 17 of 100 people with = pancreatic cancer=20 survive for a year after their diagnosis after=20 traditional chemotherapy is used, but Dr. Moore = says=20 that in itself is a small miracle; 15 years ago = when Dr.=20 Moore entered the field, no one with pancreatic = cancer=20 lived to mark the anniversary of a = diagnosis.

But with chemo and erlotinib - sold under the = brand=20 name Tarceva - 24 of 100 patients survived to = one=20 year.

Dr. Moore says even though the improvement is = small,=20 it is still important because it's better, but = he says=20 they obviously have a long way to go.

Heather Logan, director of cancer control = policy at=20 the Canadian Cancer Society, says the gains = translate,=20 on average, into an extra two weeks of life, = although=20 modest, when life expectancy is measured in = weeks,=20 modest gains are real gains, and any advances = made to=20 help people living with pancreatic cancer is a = step in=20 the right direction. She hopes the next study = will build=20 on that.

Pancreatic cancer is one of what are often = called=20 silent forms of the disease, producing few = symptoms=20 until the cancer is advanced. But unlike some = forms of=20 cancer, which have high cure rates even if found = early,=20 pancreatic cancer remains a very difficult = disease to=20 treat regardless of when it is diagnosed.

Dr. Moore says that only 15 per cent of cases = are=20 found early enough to undergo surgery to remove = most of=20 the pancreas. The pancreas produces essential = insulin,=20 so total removal is not a practical option, and = only 15=20 per cent of those who undergo surgery are cured = by=20 it.

The average survival time from diagnosis is = in fact=20 just over six months, and only two per cent of = people=20 who are diagnosed with pancreatic cancer survive = to five=20 years.

Erlotinib is not currently approved in = Canada. It is=20 available in the United States, where it is = licensed for=20 the treatment of lung cancer.

Roche, which distributes the = drug,=20 applied late last year to bring it to market in = Canada=20 as a lung cancer therapy. Roche Canada = spokeswoman=20 Samantha Ouimet said Friday the company is = hoping Health=20 Canada will approve the drug this summer.

 

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